GTF2H4
Sign in to saveAlso known as general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.
Gene data
GTF2H4- Name
- general transcription factor IIH subunit 4
- Type
- protein-coding
- Position
- 30,907,522–30,914,119 (+)
- Aliases
- P52, TFB2, TFIIH, XPJ
- Ensembl
- ENSG00000226384
- RefSeq RNA
- NM_001517.5
- RefSeq protein
- NP_001508.1
Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
Basal transcription factors - Homo sapiens (human)Nucleotide excision repair - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Formation of RNA Pol II elongation complex Formation of the Early Elongation ComplexHIV Life CycleLate Phase of HIV Life CycleHIV InfectionDiseaseFormation of HIV elongation complex in the absence of HIV Tat
via MyGene.info
Research
25 papers- GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases.Innovation (Cambridge (Mass.)) · 2024
- XP-J, a ninth xeroderma pigmentosum complementation group, results from mutations in GTF2H4, encoding TFIIH-p52 subunit.The Journal of clinical investigation · 2025
- Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study.International journal of genomics · 2025
- [Bioinformatics-based analysis of the effect of general Transcription Factor IIH on prognosis of Prostate cancer].Zhonghua yi xue za zhi · 2024
- Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes.Clinical epigenetics · 2019
via PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 7090
- exact match
- identifiers.org/ncbigene/2968
- genomic end
- 30914106
- genomic start
- 30908207
- cytogenetic location
- 6p21.33
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.
== Interactions ==
Connections
Q180686
Entity
human chromosome 6
Entity
homeobox
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Ensembl genome database project
Entity
TBP
Gene
transcription factor TFIIH holo complex
Entity
general transcription factor IIB
Protein
PDX1
Gene
protein
Entity
Wikidata
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gene
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chromosome
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digital object identifier
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bibcode
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human genome
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Q229883
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base pair
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Medical Subject Headings
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locus
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gene expression
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