HDAC5

Also known as HD5, NY-CO-9, histone deacetylase 5

protein-coding gene in the species Homo sapiens

Gene data

HDAC5

Name: histone deacetylase 5
Type: protein-coding
Position: 44,076,746–44,123,702 (−)
Aliases: HD5, NY-CO-9
Ensembl: ENSG00000108840
RefSeq RNA: NM_001015053.2, NM_001382393.1, NM_005474.5, NM_139205.1, XM_011524149.3
RefSeq protein: NP_001015053.1, NP_001369322.1, NP_005465.2, XP_011522451.1, XP_047291003.1

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].