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GeneQ18028999· pop 5· linked from 819 articles

MEF2A

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Also known as ADCAD1, RSRFC4, RSRFC9, mef2, myocyte enhancer factor 2A

protein-coding gene in the species Homo sapiens

Gene data

MEF2A

Name: myocyte enhancer factor 2A
Type: protein-coding
Position: 99,565,372–99,716,488 (+)
Aliases: ADCAD1, RSRFC4, RSRFC9, mef2
Ensembl: ENSG00000068305
RefSeq RNA: NM_001130926.5, NM_001130927.5, NM_001130928.4, NM_001171894.5, NM_001319206.4
RefSeq protein: NP_001124398.1, NP_001124399.1, NP_001124400.1, NP_001165365.1, NP_001306135.1

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II DNA-templated transcription heart development muscle organ development positive regulation of cardiac muscle hypertrophy positive regulation of cardiac muscle hypertrophy positive regulation of gene expression cell differentiation

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

cGMP-PKG signaling pathway - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Fluid shear stress and atherosclerosis - Homo sapiens (human)Developmental Biology Cytokine Signaling in Immune system Signal Transduction Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade

via MyGene.info

Gene · Ensembl

myocyte enhancer factor 2A

Symbol: MEF2A
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:99,565,372-99,716,488
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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