Heparanase
Sign in to saveAlso known as HPSE, heparanase-1, Hpa1, endo-glucoronidase
Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides.
Protein · UniProt
Heparanase
- Gene
- HPSE
- Organism
- Homo sapiens (Human)
- Length
- 543 aa
- Molecular mass
- 61,149 Da
- Evidence
- 1: Evidence at protein level
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but beco…
Swiss-Prot (reviewed) · via UniProt
Research
2,144 papers- Heparanase and the hallmarks of cancer.Journal of translational medicine · 2020
- Heparanase in Kidney Disease.Advances in experimental medicine and biology · 2020
- Heparanase in the Coagulation System.Advances in experimental medicine and biology · 2020
- Heparanase: Cloning, Function and Regulation.Advances in experimental medicine and biology · 2020
- Heparanase and Type 1 Diabetes.Advances in experimental medicine and biology · 2020
via PubMed
Clinical Trials
7 registered- COMPLETEDUrinary Heparanase Activity as a Predictor of Acute Kidney Injury in Critically Ill AdultsDenver Health and Hospital Authority · NCT01900275
- COMPLETEDLacritin and Heparanase Levels in Human Tears After Laser Refractive SurgeryFort Belvoir Community Hospital · NCT01049724
- COMPLETEDPharmacokinetics of Low Molecular Weight Heparin in Cancer PatientsShaare Zedek Medical Center · NCT00716898
- COMPLETEDThe Expression Heparanase in Term and Preterm PlacentasHillel Yaffe Medical Center · NCT03798964
- PHASE1COMPLETEDSST0001 (Roneparstat) in Advanced Multiple MyelomaSigma Tau Research Switzerland SA · NCT01764880
- PHASE2COMPLETEDPilot Efficacy Study of PI-88 With Docetaxel to Treat Prostate CancerProgen Pharmaceuticals · NCT00268593
Wikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular matrix
- found in taxon
- Homo sapiens
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Synthesis and structure
- Function
- Clinical significance
- References
- Further reading
- External links
Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides.
== Synthesis and structure ==
Excerpted from Wikipedia’s “Heparanase” article, available under the CC BY-SA 4.0 licence.
Available in 7 languages
via Wikidata sitelinks · CC0