High mobility group box 1

Protein · UniProt

High mobility group protein B1

Gene

HMGB1

Organism

Homo sapiens (Human)

Length

215 aa

Molecular mass

24,894 Da

Evidence

1: Evidence at protein level

Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/…

• High Mobility Group Box-1 and Blood-Brain Barrier Disruption.Cells · 2020
• High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies.Journal of hematology & oncology · 2020
• High-Mobility Group Box 1 (HMGB1) Protein in Parkinson's Disease Research: A 10-Year Bibliometric Analysis.Journal of integrative neuroscience · 2023
• High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders.Cells · 2021
• High Mobility Group Box 1 and Cardiovascular Diseases: Study of Act and Connect.Cardiovascular toxicology · 2024

via PubMed

• UNKNOWN
  MiRNA223 and HMGB1 as Apredictos for Drug Resistant EpilepsyAssiut University · NCT05555537
• UNKNOWN
  Clinical Implications of HMGB1 in Patients Treated With Chemotherapy or Hematopoietic Stem Cell TransplantationSeoul St. Mary's Hospital · NCT02044185
• COMPLETED
  Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart SurgeryYonsei University · NCT02490644
• COMPLETED
  Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Off-pump Coronary Artery Bypass GraftYonsei University · NCT02206412

via ClinicalTrials.gov