HORMAD1
Sign in to saveAlso known as CT46, NOHMA, HORMA domain containing 1
HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1 gene.
Gene data
HORMAD1- Name
- HORMA domain containing 1
- Type
- protein-coding
- Aliases
- CT46, NOHMA
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
via MyGene.info
Gene · Ensembl
HORMA domain containing 1
- Symbol
- HORMAD1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:150,698,059-150,720,895
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 69415
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/84072
- genomic end
- 150720895
- genomic start
- 150670536
- chromosome
- human chromosome 1
- cytogenetic location
- 1q21.3
- expressed in
- appendix
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Role in cancer
- References
- Further reading
HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1 gene.
== Function == HORMAD1 is a cancer/testis antigen that plays a key role in meiotic progression. It has shown to regulate 3 different functions during meiosis. Specifically, it: Ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity)
Excerpted from Wikipedia’s “HORMAD1” article, available under the CC BY-SA 4.0 licence.