NSFL1C

Also known as P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, NSFL1 cofactor

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

In the Vinony graph

Within Vinony's link graph, NSFL1C is referenced by 3 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 20.

Its subject is documented across 4 Wikipedia language editions.

Gene data

NSFL1C

Name: NSFL1 cofactor
Type: protein-coding
Position: 1,442,162–1,473,842 (−)
Aliases: P47, UBX1, UBXD10, UBXN2C, dJ776F14.1
Ensembl: ENSG00000088833
RefSeq RNA: NM_001206736.2, NM_016143.5, NM_018839.5, NM_182483.1, NR_038164.2
RefSeq protein: NP_001193665.1, NP_057227.2, NP_061327.2, XP_006723656.1, XP_011527602.1

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011].

Gene Ontology

Biological process

establishment of mitotic spindle orientation establishment of mitotic spindle orientation establishment of mitotic spindle orientation ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of mitotic centrosome separation positive regulation of mitotic centrosome separation positive regulation of mitotic centrosome separation

Molecular function

protein binding ubiquitin binding

Cellular component

nucleus nucleus nucleus chromosome chromosome cytoplasm Golgi stack centrosome

Pathways

Protein processing in endoplasmic reticulum - Homo sapiens (human)Signal Transduction Signaling by Rho GTPases RHO GTPase cycle RHOH GTPase cycle Signaling by Rho GTPases, Miro GTPases and RHOBTB3

via MyGene.info

Gene · Ensembl

NSFL1 cofactor

Symbol: NSFL1C
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:1,442,162-1,473,842
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein NSFL1C PDB 1i42.png

Show 9 more facts

HomoloGene ID: 41114
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/55968
genomic end: 1454487
genomic start: 1422807
chromosome: human chromosome 20
cytogenetic location: 20p13
expressed in: monocyte
Commons category: NSFL1C

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.

Excerpted from Wikipedia’s “NSFL1C” article, available under the CC BY-SA 4.0 licence.