HSF4
Sign in to saveAlso known as CTM, CTRCT5, heat shock transcription factor 4
gen de la especie Homo sapiens
Gene data
HSF4- Name
- heat shock transcription factor 4
- Type
- protein-coding
- Position
- 67,164,681–67,169,945 (+)
- Aliases
- CTM, CTRCT5
- Ensembl
- ENSG00000102878
- RefSeq RNA
- NM_001040667.3, NM_001374674.1, NM_001374675.1, NM_001538.4
- RefSeq protein
- NP_001035757.1, NP_001361603.1, NP_001361604.1, NP_001529.2
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
heat shock transcription factor 4
- Symbol
- HSF4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:67,164,681-67,169,945
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 100128
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3299
- genomic end
- 67203848
- genomic start
- 67197288
- chromosome
- human chromosome 16
- cytogenetic location
- 16q22.1
via Wikidata · CC0
Article · Español
La proteína 4 del factor de choque térmico es una proteína que en humanos está codificada por el gen HSF4. Los factores de transcripción de choque térmico (HSF) activan los genes de respuesta al choque térmico en condiciones de calor u otras tensiones. HSF4 carece de la repetición hidrófoba carboxilo-terminal que se comparte entre todos los HSF de vertebrados y se ha sugerido que está involucrado en la regulación negativa de la actividad de unión al ADN. Se han descrito dos transcripciones empalmadas alternativamente que codifican distintas isoformas y poseen diferente actividad transcripcional.
Abstract from DBpedia / Wikipedia · CC BY-SA