hyaluronidase
Sign in to saveAlso known as Hydase, Hyalase, Wydase, Jalovis, Kinetin, Amphadase, HYAL-1, Hyaluronidase PH-20
Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid. Karl Meyer classified these enzymes in 1971, into three distinct groups, a scheme based on the enzyme reaction products. The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of glycosidase.
Key facts
- Enzyme.EC_number
- 3.2.1.35
- Enzyme.CAS_number
- 37326-33-3
- Enzyme.GO_code
- 0004415
- Enzyme.image
- Hyaluronidase 1 2PE4.png
- Protein family.Symbol
- Hyaluronidase_2
- Protein family.caption
- the partial structure of a group a streptococcal phage-encoded tail fibre hyaluronate lyase hylp2
- Protein family.Pfam
- PF07555
- Protein family.InterPro
- IPR011496
- Drug.tradename
- Hylenex, Hyqvia, Vitrase, others
- Drug.DailyMedID
- Hyaluronidase
- Drug.pregnancy_AU_comment
- Exempt
- Drug.routes_of_administration
- Subcutaneous
- Drug.ATC_prefix
- B06
- Drug.ATC_suffix
- AA03
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 9001-54-1
via Wikipedia infobox
Research
13,878 papers- Clinical Applications of Hyaluronidase.Advances in experimental medicine and biology · 2019
- Hyaluronidase 6 Does Not Affect Cumulus-Oocyte Complex Dispersal and Male Mice Fertility.Genes · 2022
- Hyaluronidase Caveats in Treating Filler Complications.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2015
- Hyaluronidase inhibitor delphinidin inhibits cancer metastasis.Scientific reports · 2024
- [Hyaluronidase].Svensk farmaceutisk tidskrift · 1961
via PubMed
~10 min read
Encyclopedic overview
11 sectionsContents
- <span class="anchor" id="Use as a drug"></span>Use as a drug
- Medical uses
- Purified and recombinant hyaluronidases
- Combination treatments
- Role in cancer
- Role in pathogenesis
- Role in immune response
- Role in sepsis and septic shock
- Role in fertilization
- References
- External links
Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid. Karl Meyer classified these enzymes in 1971, into three distinct groups, a scheme based on the enzyme reaction products. The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of glycosidase.
In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYAL3, HYAL4 and HYAL5 (also known as SPAM1 or PH-20); plus a pseudogene, HYAL6 (also known as HYALP1). The genes for HYAL1-3 are clustered in chromosome 3, while HYAL4-6 are clustered in chromosome 7. HYAL1 and HYAL2 are the major hyaluronidases in most tissues. GPI-anchored HYAL2 is responsible for cleaving high-molecular weight hyaluronic acid, which is mostly bound to the CD44 receptor. The resulting hyaluronic acid fragments of variable size are then further hydrolyzed by HYAL1 after being internalized into endo-lysosomes; this generates hyaluronic acid oligosaccharides.
Excerpted from Wikipedia’s “hyaluronidase” article, available under the CC BY-SA 4.0 licence.