IGFBP1
Sign in to saveAlso known as AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1
Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.
Gene data
IGFBP1- Name
- insulin like growth factor binding protein 1
- Type
- protein-coding
- Position
- 45,888,360–45,893,660 (+)
- Aliases
- AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1
- Ensembl
- ENSG00000146678
- RefSeq RNA
- NM_000596.4, NM_001013029.1, XM_054358118.1
- RefSeq protein
- NP_000587.1, XP_054214093.1
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin like growth factor binding protein 1
- Symbol
- IGFBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:45,888,360-45,893,660
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.
== Function ==
Excerpted from Wikipedia’s “IGFBP1” article, available under the CC BY-SA 4.0 licence.