IGFBP3
Sign in to saveAlso known as BP-53, IBP3, insulin like growth factor binding protein 3
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes included in this family, shares neither the conserved structural features nor the high IGF affinity. Instead, IGFBP-7 binds IGF1R, which blocks IGF-1 and IGF-2 binding, resulting in apoptosis.
Gene data
IGFBP3- Name
- insulin like growth factor binding protein 3
- Type
- protein-coding
- Position
- 45,912,245–45,921,874 (−)
- Aliases
- BP-53, IBP-3, IBP3, IGFBP-3
- Ensembl
- ENSG00000146674
- RefSeq RNA
- NM_000598.5, NM_001013398.2, XM_047420325.1, XM_054358119.1
- RefSeq protein
- NP_000589.2, NP_001013416.1, XP_047276281.1, XP_054214094.1
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin like growth factor binding protein 3
- Symbol
- IGFBP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:45,912,245-45,921,874
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 500
- exact match
- identifiers.org/ncbigene/3486
- genomic end
- 45961473
- genomic start
- 45951949
- cytogenetic location
- 7p12.3
- Commons category
- Insulin-like growth factor-binding protein 3
via Wikidata · CC0
~13 min read
Article
13 sectionsContents
- Gene
- Tissue distribution
- Structure
- Function
- Regulation
- Clinical significance
- Cancer
- Sepsis
- Interactions
- See also
- Notes
- References
- Further reading
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes included in this family, shares neither the conserved structural features nor the high IGF affinity. Instead, IGFBP-7 binds IGF1R, which blocks IGF-1 and IGF-2 binding, resulting in apoptosis.
== Gene ==