IGFBP4
Sign in to saveAlso known as BP-4, HT29-IGFBP, IBP4, IGFBP-4, insulin like growth factor binding protein 4
Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.
Gene data
IGFBP4- Name
- insulin like growth factor binding protein 4
- Type
- protein-coding
- Position
- 40,442,913–40,460,822 (+)
- Aliases
- BP-4, HT29-IGFBP, IBP4, IGFBP-4
- Ensembl
- ENSG00000141753
- RefSeq RNA
- NM_001552.3
- RefSeq protein
- NP_001543.2
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin like growth factor binding protein 4
- Symbol
- IGFBP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:40,442,913-40,460,822
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein IGFBP4 PDB 1wqj.png
Show 9 more facts
- HomoloGene ID
- 1192
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3487
- genomic end
- 40457725
- genomic start
- 40443450
- chromosome
- human chromosome 17
- cytogenetic location
- 17q21.2
- expressed in
- smooth muscle tissue
- Commons category
- Insulin-like growth factor-binding protein 4
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.
== Function ==
Excerpted from Wikipedia’s “IGFBP4” article, available under the CC BY-SA 4.0 licence.