iobenguane I-131
Sign in to saveIobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical. It acts as a blocking agent for adrenergic neurons. When radiolabeled, it can be used in nuclear medicinal diagnostic and therapy techniques as well as in neuroendocrine chemotherapy treatments.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459443348
- Drug.image
- Iobenguane.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Adreview, Azedra
- Drug.DailyMedID
- Iobenguane
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- V09
- Drug.ATC_suffix
- IX01
- Drug.ATC_supplemental
- (123I) (131I, diagnostic) (131I, therapeutic)
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.CAS_number
- 80663-95-2
- Drug.CAS_number2
- 76924-93-1
- Drug.CAS_supplemental
- 77679-27-7
- Drug.PubChem
- 60860
- Drug.PubChem2
- 135326 <!--
via Wikipedia infobox
Wikidata facts
- Mass
- 278.994
- Has use
- medication
Show 5 more facts
- canonical SMILES
- C1=CC(=CC(=C1)I)CN=C(N)N
- chemical formula
- C₈H₁₀IN₃
- subject has role
- enzyme inhibitor
- isomeric SMILES
- C1=CC(=CC(=C1)[131I])CN=C(N)N
- World Health Organisation international non-proprietary name
- iobenguane
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Usage and mechanism
- Metabolites and excretion
- Diagnostic imaging
- Side effects
- Radionuclide therapy
- Thyroid precautions
- Clinical trials
- Iobenguane I 131 for cancers
- References
- External links
Iobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical. It acts as a blocking agent for adrenergic neurons. When radiolabeled, it can be used in nuclear medicinal diagnostic and therapy techniques as well as in neuroendocrine chemotherapy treatments.
It localizes to adrenergic tissue and thus can be used to identify the location of tumors such as pheochromocytomas and neuroblastomas. With iodine-131 it can also be used to treat tumor cells that take up and metabolize norepinephrine.
Excerpted from Wikipedia’s “iobenguane I-131” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0