iobenguane I-131

Iobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical. It acts as a blocking agent for adrenergic neurons. When radiolabeled, it can be used in nuclear medicinal diagnostic and therapy techniques as well as in neuroendocrine chemotherapy treatments.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 459443348
Drug.image: Iobenguane.svg
Drug.image_class: skin-invert-image
Drug.tradename: Adreview, Azedra
Drug.DailyMedID: Iobenguane
Drug.routes_of_administration: Intravenous
Drug.ATC_prefix: V09
Drug.ATC_suffix: IX01
Drug.ATC_supplemental: (123I) (131I, diagnostic) (131I, therapeutic)
Drug.legal_US: Rx-only
Drug.legal_status

Article

10 sections

Contents

Usage and mechanism
Metabolites and excretion
Diagnostic imaging
Side effects
Radionuclide therapy
Thyroid precautions
Clinical trials
Iobenguane I 131 for cancers
References
External links

It localizes to adrenergic tissue and thus can be used to identify the location of tumors such as pheochromocytomas and neuroblastomas. With iodine-131 it can also be used to treat tumor cells that take up and metabolize norepinephrine.