radioimmunotherapy
Sign in to saveRadioimmunotherapy (RIT) uses an antibody labeled with a radionuclide to deliver cytotoxic radiation to a target cell. It is a form of unsealed source radiotherapy. In cancer therapy, an antibody with specificity for a tumor-associated antigen is used to deliver a lethal dose of radiation to the tumor cells. The ability for the antibody to specifically bind to a tumor-associated antigen increases the dose delivered to the tumor cells while decreasing the dose to normal tissues. By its nature, RIT requires a tumor cell to express an antigen that is unique to the neoplasm or is not accessible in
Research
5,408 papers- Radioimmunotherapy in colorectal cancer treatment: present and future.Frontiers in immunology · 2023
- PAI-1-driven SFRP2(high) cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.Cancer cell · 2025
- Radioimmunotherapy for the treatment of infectious diseases: a comprehensive update.Expert review of anti-infective therapy · 2023
- Combination Radioimmunotherapy Strategies for Solid Tumors.International journal of molecular sciences · 2019
- Cancer radioimmunotherapy.Immunotherapy · 2011
via PubMed
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Encyclopedic overview
5 sectionsContents
- History of available agents
- Agents in clinical development
- Other applications (non-approved indications)
- References
- External links
Radioimmunotherapy (RIT) uses an antibody labeled with a radionuclide to deliver cytotoxic radiation to a target cell. It is a form of unsealed source radiotherapy. In cancer therapy, an antibody with specificity for a tumor-associated antigen is used to deliver a lethal dose of radiation to the tumor cells. The ability for the antibody to specifically bind to a tumor-associated antigen increases the dose delivered to the tumor cells while decreasing the dose to normal tissues. By its nature, RIT requires a tumor cell to express an antigen that is unique to the neoplasm or is not accessible in normal cells.
==History of available agents==
Excerpted from Wikipedia’s “radioimmunotherapy” article, available under the CC BY-SA 4.0 licence.