IRF5

Also known as SLEB10, interferon regulatory factor 5

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.

Gene data

IRF5

Name: interferon regulatory factor 5
Type: protein-coding
Position: 128,933,429–128,950,389 (+)
Aliases: SLEB10
Ensembl: ENSG00000128604
RefSeq RNA: NM_001098627.4, NM_001098629.3, NM_001098630.3, NM_001242452.3, NM_001347928.2
RefSeq protein: NP_001092097.2, NP_001092099.1, NP_001092100.1, NP_001229381.1, NP_001334857.1

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016].

Gene Ontology

Biological process

immune system process positive regulation of cytokine production involved in immune response regulation of DNA-templated transcription regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway positive regulation of type I interferon production

Molecular function

transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm

Pathways

Toll-like receptor signaling pathway - Homo sapiens (human)Cytokine Signaling in Immune system Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor 7/8 (TLR7/8) Cascade Innate Immune System Immune System Toll-like Receptor Cascades Interferon gamma signaling Interferon alpha/beta signaling Interferon Signaling

via MyGene.info

Gene · Ensembl

interferon regulatory factor 5

Symbol: IRF5
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:128,933,429-128,950,389
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 8088
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3663
genomic end: 128950038
genomic start: 128937457
chromosome: human chromosome 7
cytogenetic location: 7q32.1
expressed in: right coronary artery

Sources (5)

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Encyclopedic overview

7 sections

Contents

Function
Clinical significance
Signaling
See also
References
Further reading
External links

== Function ==

Excerpted from Wikipedia’s “IRF5” article, available under the CC BY-SA 4.0 licence.

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IRF5

Gene data

Gene Ontology

Pathways

Gene · Ensembl

Wikidata facts

Encyclopedic overview

Available in 9 languages

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What links here837 pages