isozima
Sign in to saveAlso known as isoenzymes, multiple forms of enzymes, izoenzymy, isoenzyme, isozymes
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes or isoforms) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. different KM values), or are regulated differently. They permit the fine-tuning of metabolism to meet the particular needs of a given tissue or developmental stage.
Research
101,232 papers- Protein kinase C (PKC) isozyme-specific substrates and their design.Biotechnology advances · 2012
- Clinical and biological significance of an isozyme tumor marker--PLAP.Clinical biochemistry · 1987
- [Isozyme analysis by enzyme immunoassay (EIA)--clinical significance and future prospect].Nihon rinsho. Japanese journal of clinical medicine · 1995
- [Lactate dehydrogenase (LDH)].Nihon rinsho. Japanese journal of clinical medicine · 1995
- Protein kinase C isozyme selective peptides--a current view of what they tell us about location and function of isozymes in the heart.Current pharmaceutical design · 2005
via PubMed
Wikidata facts
- Subclass of
- enzyme
Show 1 more fact
- Commons category
- Isoenzymes
Sources (2)
via Wikidata · CC0
Article · Português
As isozimas ou isoenzimas são enzimas que diferem na sequência de aminoácidos, mas que catalisam a mesma reação química. Estas enzimas podem mostrar diferentes parâmetros cinéticos (i.e. diferentes valores de KM), ou propriedades de regulação diferentes. A existência das isozimas permite o ajuste do metabolismo para satisfazer as necessidades particulares de um determinado tecido ou etapa de desenvolvimento. Em bioquímica, as isozimas são (variantes estreitamente relacionadas) das enzimas. Em muitos casos, são codificadas por genes homólogos que divergiram com o tempo. Ainda que de forma estrita, as isoenzimas representam enzimas de diferentes alelos de um mesmo gene e as isozimas representam enzimas de diferentes genes cujos produtos catalisam a mesma reação. As duas terminologias podem-se usar indistintamente.
Abstract from DBpedia / Wikipedia · CC BY-SA