steroid 5-alpha reductase
thumb|235px|right|class=skin-invert-image|Steroidogenesis, showing both actions of 5α-reductase at bottom center.
Key facts
- Enzyme.Name
- 3-Oxo-5α-steroid 4-dehydrogenase
- Enzyme.EC_number
- 1.3.1.22
- Enzyme.CAS_number
- 9036-43-5
- Enzyme.GO_code
- 0003865
- Enzyme.image
- File:PbSDR5A steroid 5-alpha-reductase PDB=7c83.png
- Enzyme.caption
- Bacterial SDR5A in complex with NADPH and monoolein
- Enzyme.image_size
- 150
- Protein.Name
- Steroid-5α-reductase 2
- Protein.HGNCid
- 11285
- Protein.Symbol
- SRD5A2
- Protein.EntrezGene
- 6716
- Protein.OMIM
- 607306
- Protein.RefSeq
Article
21 sectionsContents
- Production and activity
- Distribution with age
- Substrates
- Testosterone
- List of conversions
- Structure
- Inhibition
- Finasteride
- Dutasteride
- Congenital deficiencies
- 5α-Reductase 1
- 5α-Reductase 2
- 5α-Reductase 3
- Nervous system
- Affective disorders
- Hypothalamic–pituitary–adrenal axis dysfunction
- Nomenclature
- See also
- References
- Further reading
- External links
thumb|235px|right|class=skin-invert-image|Steroidogenesis, showing both actions of 5α-reductase at bottom center.
5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in three metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isozymes of 5α-reductase encoded by the genes SRD5A1, SRD5A2, and SRD5A3.