Structure via PubChem · Public domain (PubChem)
propylthiouracil
Sign in to saveAlso known as Thyreostat®, 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 6-propyl-2-thiouracil, 4-propyl-2-thiouracil, 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 6-Thio-4-propyluracil, 2-Mercapto-6-propylpyrimid-4-one, 2-Thio-6-propyl-1,3-pyrimidin-4-one
Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. In a thyrotoxic crisis it is generally more effective than methimazole. Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible. It is taken by mouth.
Chemical data
- Formula
- C7H10N2OS
- Molecular weight
- 170.23 g/mol
- IUPAC name
- 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
- SMILES
- CCCC1=CC(=O)NC(=S)N1
- InChIKey
- KNAHARQHSZJURB-UHFFFAOYSA-N
- XLogP
- 0.8
- Polar surface area
- 73.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
6,039 papers- Propylthiouracil for alcoholic liver disease.The Cochrane database of systematic reviews · 2005
- Propylthiouracil.Report on carcinogens : carcinogen profiles · 2011
- Antithyroid drugs.The New England journal of medicine · 2005
- Propylthiouracil-associated hepatitis.Journal of the National Medical Association · 1991
- Propylthiouracil.Report on carcinogens : carcinogen profiles · 2004
via PubMed
Wikidata facts
- Mass
- 170.051
Show 6 more facts
- chemical formula
- C₇H₁₀N₂OS
- canonical SMILES
- CCCC1=CC(=O)NC(=S)N1
- Commons category
- Propylthiouracil
- World Health Organisation international non-proprietary name
- propylthiouracil
- defined daily dose
- 0.1
- MCN code
- 2933.59.31
via Wikidata · CC0
~7 min read
Article
11 sectionsContents
- Side effects
- Pregnancy
- Mechanism of action
- Thyroid
- T3/T4 target tissues
- Pharmacokinetics
- Chemical synthesis
- Role in taste
- History
- References
- External links
Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. In a thyrotoxic crisis it is generally more effective than methimazole. Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible. It is taken by mouth.
Common side effects include itchiness, hair loss, parotid swelling, vomiting, muscle pains, numbness, and headache. Other severe side effects include liver problems and low blood cell counts. Use during pregnancy may harm the baby. Propylthiouracil is in the antithyroid family of medications. It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3).