Structure via PubChem · Public domain (PubChem)
JWH-073
Sign in to saveJWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5× the affinity at CB2. The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.
Chemical data
- Formula
- C23H21NO
- Molecular weight
- 327.4 g/mol
- IUPAC name
- (1-butylindol-3-yl)-naphthalen-1-ylmethanone
- SMILES
- CCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43
- InChIKey
- VCHHHSMPMLNVGS-UHFFFAOYSA-N
- XLogP
- 5.8
- Polar surface area
- 22 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
131 papers- Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice.Frontiers in psychiatry · 2022
- JWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeys.The Journal of pharmacology and experimental therapeutics · 2012
- Deposition of JWH-018, JWH-073 and their metabolites in hair and effect of hair pigmentation.Analytical and bioanalytical chemistry · 2013
- Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine.Analytical chemistry · 2011
- Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice.Progress in neuro-psychopharmacology & biological psychiatry · 2016
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 327.162
Show 3 more facts
- chemical formula
- C₂₃H₂₁NO
- canonical SMILES
- CCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43
- Commons category
- JWH-073
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Pharmacology
- Derivatives
- Legal status
- United States
- Australia
- New Zealand
- Turkey
- Germany
- See also
- References
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5× the affinity at CB2. The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.
On 20 April 2009, JWH-073 was claimed by researchers at the University of Freiburg to have been found in a "fertiliser" product called "Forest Humus", along with another synthetic cannabinoid (C8)-CP 47,497. These claims were confirmed in July 2009 when tests of Spice product, seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound JWH-073 instead.
Excerpted from Wikipedia’s “JWH-073” article, available under the CC BY-SA 4.0 licence.