KAT5
Sign in to saveAlso known as ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2
Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene. It is also commonly identified as TIP60.
Gene data
KAT5- Name
- lysine acetyltransferase 5
- Type
- protein-coding
- Position
- 65,711,992–65,719,604 (+)
- Aliases
- ESA1, HTATIP, HTATIP1, NEDFASB, PLIP, TIP, TIP60, ZC2HC5, cPLA2
- Ensembl
- ENSG00000172977
- RefSeq RNA
- NM_001206833.2, NM_006388.4, NM_182709.3, NM_182710.3, XM_006718421.4
- RefSeq protein
- NP_001193762.1, NP_006379.2, NP_874368.1, NP_874369.1, XP_006718484.1
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lysine acetyltransferase 5
- Symbol
- KAT5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,711,992-65,719,604
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~5 min read
Encyclopedic overview
14 sectionsContents
- Structure
- Function
- Transcription
- DNA repair
- Apoptosis
- Regulation
- Clinical relevance
- Cancer
- HIV
- Aging and Neurodegeneration
- Interactions
- References
- Further reading
- External links
Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene. It is also commonly identified as TIP60.
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
Excerpted from Wikipedia’s “KAT5” article, available under the CC BY-SA 4.0 licence.