CAMP responsive element binding protein 1
Sign in to saveAlso known as cyclic adenosine 3',5'-monophosphate response element-binding protein CREB, cyclic adenosine 3',5'-monophosphate response element binding protein, CREB1, cAMP-response element-binding protein-1, transactivator protein, cyclic AMP-responsive element-binding protein 1, active transcription factor CREB
CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.
Protein · UniProt
Cyclic AMP-responsive element-binding protein 1
- Gene
- CREB1
- Organism
- Homo sapiens (Human)
- Length
- 327 aa
- Molecular mass
- 35,136 Da
- Evidence
- 1: Evidence at protein level
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERF…
Swiss-Prot (reviewed) · via UniProt
Research
1,260 papers- CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients.Nature communications · 2023
- Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management.Theranostics · 2024
- cAMP responsive element binding protein 1: a missing link for heart rate regulation?Circulation. Cardiovascular genetics · 2010
- Margarita (Pearl) Extract Alleviates Melasma by Targeting CAMP-Responsive Element Binding Protein 1.Journal of cosmetic dermatology · 2025
- miR-205 Inhibits Neuroblastoma Growth by Targeting cAMP-Responsive Element-Binding Protein 1.Oncology research · 2018
via PubMed
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Encyclopedic overview
5 sectionsContents
- See also
- Interactions
- References
- Further reading
- External links
CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.
This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “CAMP responsive element binding protein 1” article, available under the CC BY-SA 4.0 licence.