EDNRA
Sign in to saveAlso known as ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
protein-coding gene in the species Homo sapiens
Gene data
EDNRA- Name
- endothelin receptor type A
- Type
- protein-coding
- Position
- 147,480,769–147,544,954 (+)
- Aliases
- ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR
- Ensembl
- ENSG00000151617
- RefSeq RNA
- NM_001166055.2, NM_001256283.1, NM_001354797.2, NM_001957.4, NR_045958.2
- RefSeq protein
- NP_001159527.1, NP_001341726.1, NP_001948.1
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
Calcium signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)Renin secretion - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)
via MyGene.info
Gene · Ensembl
endothelin receptor type A
- Symbol
- EDNRA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:147,480,769-147,544,954
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI