BCL3

Also known as BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, BCL3, transcription coactivator, BCL3 transcription coactivator

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

Gene data

BCL3

Name: BCL3 transcription coactivator
Type: protein-coding
Position: 44,747,705–44,760,044 (+)
Aliases: BCL4, D19S37
Ensembl: ENSG00000069399
RefSeq RNA: NM_005178.5, XM_011527198.4, XM_017027110.2, XM_054321686.1, XM_054321687.1
RefSeq protein: NP_005169.2, XP_011525500.3, XP_016882599.1, XP_054177661.1, XP_054177662.1

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].

Pathways

C-type lectin receptor signaling pathway - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Apoptosis-related network due to altered Notch3 in ovarian cancer

via MyGene.info

Gene · Ensembl

BCL3 transcription coactivator

Symbol: BCL3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:44,747,705-44,760,044
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

7 sections

Contents

Interactions
Clinical significance
Role in cancer therapy
Development
References
Further reading
External links

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Excerpted from Wikipedia’s “BCL3” article, available under the CC BY-SA 4.0 licence.