LASP1
Sign in to saveAlso known as MLN50, LIM and SH3 protein 1, LASP-1
LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.
Gene data
LASP1- Name
- LIM and SH3 protein 1
- Type
- protein-coding
- Position
- 38,869,185–38,921,771 (+)
- Aliases
- Lasp-1, MLN50
- Ensembl
- ENSG00000002834
- RefSeq RNA
- NM_001271608.2, NM_006148.4, NR_073384.2, XM_047435965.1
- RefSeq protein
- NP_001258537.1, NP_006139.1, XP_047291921.1
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
LIM and SH3 protein 1
- Symbol
- LASP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:38,869,185-38,921,771
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein LASP1 PDB 1zfo.png
Show 6 more facts
- HomoloGene ID
- 4480
- exact match
- identifiers.org/ncbigene/3927
- genomic end
- 37078023
- genomic start
- 37026112
- cytogenetic location
- 17q12
- Commons category
- LASP-1
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.
This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.