Leptomycin
Sign in to saveLeptomycins are secondary metabolites produced by Streptomyces spp.
Research
1,184 papers- Leptomycin B inhibits the proliferation, migration, and invasion of cultured gastric carcinoma cells.Bioscience, biotechnology, and biochemistry · 2020
- Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export.Annals of the New York Academy of Sciences · 1999
- Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).Biochemical and biophysical research communications · 2017
- [Leptomycin: a specific inhibitor of protein nuclear export].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme · 1999
- Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome.International journal of oncology · 2009
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 540.3450892559999
Show 5 more facts
- chemical formula
- C₃₃H₄₈O₆
- subject has role
- antifungal
- isomeric SMILES
- CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
- found in taxon
- Streptomyces
- canonical SMILES
- O=C(O)C=C(C)CC(C)C(O)C(C(=O)C(C=C(C=CCC(C=C(C=CC1OC(=O)C=CC1C)CC)C)C)C)C
Sources (2)
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Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Leptomycins are secondary metabolites produced by Streptomyces spp.
Leptomycin B (LMB) was originally discovered as a potent antifungal compound. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin. However, recent data shows that leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors in combination therapy.
Excerpted from Wikipedia’s “Leptomycin” article, available under the CC BY-SA 4.0 licence.