Structure via PubChem · Public domain (PubChem)
لپتومایسین
Sign in to saveLeptomycins are secondary metabolites produced by Streptomyces spp.
Chemical data
- Formula
- C33H48O6
- Molecular weight
- 540.7 g/mol
- IUPAC name
- (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
- SMILES
- CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
- InChIKey
- YACHGFWEQXFSBS-XYERBDPFSA-N
- XLogP
- 7.9
- Polar surface area
- 101 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
1,184 papers- Leptomycin B inhibits the proliferation, migration, and invasion of cultured gastric carcinoma cells.Bioscience, biotechnology, and biochemistry · 2020
- Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export.Annals of the New York Academy of Sciences · 1999
- Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).Biochemical and biophysical research communications · 2017
- [Leptomycin: a specific inhibitor of protein nuclear export].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme · 1999
- Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome.International journal of oncology · 2009
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 540.3450892559999
Show 5 more facts
- chemical formula
- C₃₃H₄₈O₆
- subject has role
- antifungal
- isomeric SMILES
- CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
- found in taxon
- Streptomyces
- canonical SMILES
- O=C(O)C=C(C)CC(C)C(O)C(C(=O)C(C=C(C=CCC(C=C(C=CC1OC(=O)C=CC1C)CC)C)C)C)C
Sources (2)
via Wikidata · CC0