ルフェヌロン

Also known as N-((2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamide, Lufenuron, N-({[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino}carbonyl)-2,6-difluorobenzamide, 1-(2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)-3-(2,6-difluorobenzoyl)urea, Fluphenacur

Lufenuron is the active ingredient in the veterinary flea control medication program, and one of the two active ingredients in the flea, heartworm, and anthelmintic medicine milbemycin oxime/lufenuron (Sentinel).

In the Vinony graph

Vinony's link graph records 218 inbound references to ルフェヌロン, and connects out to fungi, International Standard Book Number and Lepidoptera.

It is catalogued under topics including Acylureas, Antifungals and Benzamides.

Vinony links it to 12 Wikipedia language editions.

Chemical data

Formula: C17H8Cl2F8N2O3
Molecular weight: 511.1 g/mol
IUPAC name: N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide
SMILES: C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC(=C(C=C2Cl)OC(C(C(F)(F)F)F)(F)F)Cl)F
InChIKey: PWPJGUXAGUPAHP-UHFFFAOYSA-N
XLogP: 6.4
Polar surface area: 67.4 Å²
H-bond donors: 2
H-bond acceptors: 11
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

284 papers

Dissecting the manipulation of lufenuron on chitin synthesis in Helicoverpa armigera.Pesticide biochemistry and physiology · 2024
Amlodipine and lufenuron as repurposing drugs against Sporothrix brasiliensis.PeerJ · 2023
EVALUATING BAITS WITH LUFENURON AND NITENPYRAM FOR FLEA CONTROL ON PRAIRIE DOGS (CYNOMYS SPP.) TO MITIGATE PLAGUE.Journal of wildlife diseases · 2023
Detection of Chitin Synthase Mutations in Lufenuron-Resistant Spodoptera frugiperda in China.Insects · 2022
Effects of lufenuron treatments on the growth and development of Spodoptera frugiperda (Lepidoptera: Noctuidae).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2023

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 509.978
Has use: insecticide

Show 3 more facts

chemical formula: C₁₇H₈Cl₂F₈N₂O₃
canonical SMILES: C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC(=C(C=C2Cl)OC(C(C(F)(F)F)F)(F)F)Cl)F
Commons category: Lufenuron

Sources (4)

via Wikidata · CC0

Article · 日本語

ルフェヌロン (lufenuron) とは、昆虫成長制御剤のひとつ。キチン質は節足動物の外骨格の構成成分であり、発育期に合成される。ルフェヌロンなどのキチン質合成阻害薬は、キチン質の合成を阻害することにより、幼虫の孵化および脱皮を阻害する。報告されている融点、LD50値はそれぞれ 174 ℃、>2000 mg/kg（ラット、経口）。CAS登録番号は[103055-07-8]。

Abstract from DBpedia / Wikipedia · CC BY-SA