metrifonate
Sign in to saveAlso known as Trichlorfon, Chlorophos, 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester, Methyl chlorophos, (±)-Trichlorfon
Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into the active agent dichlorvos.
Research
1,438 papers- Metrifonate.Drugs & aging · 1997
- Metrifonate for Alzheimer's disease.The Cochrane database of systematic reviews · 2006
- Metrifonate: a new agent for the treatment of Alzheimer's disease.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 1999
- Metrifonate. Summary of toxicological and pharmacological information available.Archives of toxicology · 1978
- Metrifonate. A viewpoint.Drugs & aging · 1997
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- chlorine
- Mass
- 255.923
- Has use
- insecticide
Show 7 more facts
- defined daily dose
- 40
- Commons category
- Metrifonate
- chemical formula
- C₄H₈Cl₃O₄P
- canonical SMILES
- COP(=O)(C(C(Cl)(Cl)Cl)O)OC
- subject has role
- acetylcholinesterase inhibitor
- World Health Organisation international non-proprietary name
- metrifonate
- MCN code
- 2931.39.14
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Bans and restrictions
- References
Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into the active agent dichlorvos.
It is used as an insecticide. According to the US Environmental Protection Agency trichlorfon has been used on golf course turf, home lawns, non-food contact areas of food and meat processing plants, ornamental shrubs and plants, and ornamental and baitfish ponds. Used to control caterpillars, white grubs, mole crickets, cattle lice, sod webworms, leaf miners, stink bugs, flies, ants, cockroaches, earwigs, crickets, diving beetle, water scavenger beetle, water boatman backswimmer, water scorpions, giant water bugs and pillbugs. After reregistration, a number of its uses were voluntarily restricted, and currently, it is used in nonfood areas to control flies, roaches, and ants among other pests. Outdoors it is used on ornamental plants, golf courses, and lawn grass to treat lepidopteran larvae pests, it is also used to treat flies in animal husbandry in areas that are not accessible to animals, it also used to control harvester ants.
Excerpted from Wikipedia’s “metrifonate” article, available under the CC BY-SA 4.0 licence.
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