MAP1LC3B
Sign in to saveAlso known as ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.
Gene data
MAP1LC3B- Name
- microtubule associated protein 1 light chain 3 beta
- Type
- protein-coding
- Position
- 87,383,953–87,405,090 (+)
- Aliases
- ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
- Ensembl
- ENSG00000140941
- RefSeq RNA
- NM_022818.5
- RefSeq protein
- NP_073729.1
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
microtubule associated protein 1 light chain 3 beta
- Symbol
- MAP1LC3B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:87,383,953-87,405,090
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
10 sectionsContents
- Discovery
- The ATG8 protein family
- Function
- Cytoplasmic LC3
- Nuclear LC3
- Structure
- Post-translational regulation
- References
- Further reading
- External links
Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.
== Discovery ==
Excerpted from Wikipedia’s “MAP1LC3B” article, available under the CC BY-SA 4.0 licence.