WDFY3
Sign in to saveAlso known as ALFY, ZFYVE25, WD repeat and FYVE domain containing 3, BCHS, MCPH18
WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the WDFY3 gene.
Gene data
WDFY3- Name
- WD repeat and FYVE domain containing 3
- Type
- protein-coding
- Position
- 84,668,765–84,966,924 (−)
- Aliases
- ALFY, BCHS, MCPH18, ZFYVE25
- Ensembl
- ENSG00000163625
- RefSeq RNA
- NM_014991.6, NM_178583.2, NM_178585.2, XM_005262858.6, XM_011531757.4
- RefSeq protein
- NP_055806.2, XP_005262915.1, XP_011530059.1, XP_011530061.1, XP_011530062.1
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
WD repeat and FYVE domain containing 3
- Symbol
- WDFY3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:84,668,765-84,966,924
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Biochemistry
- Clinical
- References
- Further reading
WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the WDFY3 gene.
This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Excerpted from Wikipedia’s “WDFY3” article, available under the CC BY-SA 4.0 licence.