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GeneQ18033117· pop 5· linked from 303 articles

MKNK1

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Also known as MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

Gene data

MKNK1
Name
MAPK interacting serine/threonine kinase 1
Type
protein-coding
Position
46,557,407–46,616,850 (−)
Aliases
MNK1
Ensembl
ENSG00000079277
RefSeq RNA
NM_001135553.4, NM_001377337.1, NM_001377338.1, NM_001377341.1, NM_001377342.1
RefSeq protein
NP_001129025.2, NP_001364266.1, NP_001364267.1, NP_001364270.1, NP_001364271.1

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012].

Gene Ontology

Pathways

MAPK signaling pathway - Homo sapiens (human)HIF-1 signaling pathway - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)Spry regulation of FGF signalingSignal TransductionSignaling by FGFRNegative regulation of FGFR1 signalingNegative regulation of FGFR2 signalingNegative regulation of FGFR3 signalingNegative regulation of FGFR4 signaling

via MyGene.info

Gene · Ensembl

MAPK interacting serine/threonine kinase 1

Symbol
MKNK1
Biotype
Protein coding
Organism
Homo sapiens
Location
1:46,557,407-46,616,850
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein MKNK1 PDB 2hw6.png
Show 8 more facts
HomoloGene ID
37838
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/8569
genomic end
47082515
genomic start
46557407
chromosome
human chromosome 1
cytogenetic location
1p33
expressed in
monocyte
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • Interactions
  • References
  • Further reading

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

==Interactions== MKNK1 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma.

Excerpted from Wikipedia’s “MKNK1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0