MCM4

Name

minichromosome maintenance complex component 4

Type

protein-coding

Position

47,960,185–47,979,181 (+)

Aliases

CDC21, CDC54, IMD54, NKCD, NKGCD, P1-CDC21, hCdc21

Ensembl

ENSG00000104738

RefSeq RNA

NM_005914.4, NM_182746.3

RefSeq protein

NP_005905.2, NP_877423.1

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Instance of

gene

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