mefloquine
Also known as WR-142490, GNF-Pf-5544, alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol, Ro-215998, Lariam, Mefloquin, Mefloquina
Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure. It can be used to treat mild or moderate malaria but is not recommended for severe malaria. It is taken by mouth.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458774403
- Drug.image
- Mefloquine chemical structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 185px
- Drug.tradename
- Lariam, Mephaquin, Mefliam, others
- Drug.MedlinePlus
- a603030
- Drug.DailyMedID
- Mefloquine
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- Oral
- Drug.class
- Antimalarial
- Drug.ATC_prefix
Article
20 sectionsContents
- Medical uses
- Malaria prevention
- Malaria treatment
- Resistance to mefloquine
- Contraindications
- Pregnancy and breastfeeding
- Adverse effects
- Neurologic and psychiatric
- Cardiac
- Pharmacology
- Pharmacodynamics
- Off-target activities
- Pharmacokinetics
- Chemistry
- History
- Military
- Research
- References
- Further reading
- External links
Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure. It can be used to treat mild or moderate malaria but is not recommended for severe malaria. It is taken by mouth.
Common side effects include vomiting, diarrhea, headaches, sleep disorders, and a rash. Serious side effects include potentially long-term mental health problems such as depression, hallucinations, and anxiety and neurological side effects such as poor balance, seizures, and ringing in the ears. It is therefore not recommended in people with a history of mental health problems or epilepsy. It appears to be safe during pregnancy and breastfeeding.