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oxypertine
Sign in to saveOxypertine, sold under the brand name Oxypertine among others, is an antipsychotic medication of the pertine group which was previously used in the treatment of schizophrenia but is no longer marketed. It was also evaluated for the treatment of anxiety.
Chemical data
- Formula
- C23H29N3O2
- Molecular weight
- 379.5 g/mol
- IUPAC name
- 5,6-dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
~1 min read
Encyclopedic overview
8 sectionsContents
- Pharmacology
- Pharmacodynamics
- Chemistry
- History
- Society and culture
- Names
- See also
- References
Oxypertine, sold under the brand name Oxypertine among others, is an antipsychotic medication of the pertine group which was previously used in the treatment of schizophrenia but is no longer marketed. It was also evaluated for the treatment of anxiety.
==Pharmacology== ===Pharmacodynamics=== The drug shows high affinity for the serotonin 5-HT2 and dopamine D2 receptors (Ki = 8.6nM and 30nM, respectively). It antagonizes the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly contributing to its antipsychotic effectiveness.
Excerpted from Wikipedia’s “oxypertine” article, available under the CC BY-SA 4.0 licence.