Structure via PubChem · Public domain (PubChem)
lorcaserin
Sign in to saveAlso known as APD-356, Belviq®, Lorqess
Lorcaserin, marketed under the brand name Belviq, was a weight-loss drug developed by Arena Pharmaceuticals. It reduces appetite by activating the 5-HT2C serotonin receptor in the hypothalamus, a region of the brain which is known to control appetite. It was approved in 2012, and in 2020 was removed from the market in the United States due to an increased risk of cancer detected in users of Belviq.
Chemical data
- Formula
- C11H14ClN
- Molecular weight
- 195.69 g/mol
- IUPAC name
- (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
- SMILES
- C[C@H]1CNCCC2=C1C=C(C=C2)Cl
- InChIKey
- XTTZERNUQAFMOF-QMMMGPOBSA-N
- XLogP
- 2.7
- Polar surface area
- 12 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2012
- Admin. routes
- oral
- Indications
- cardiovascular disease, obesity, liver disease, cocaine dependence
via ChEMBL · EBI
Wikidata facts
- Mass
- 195.081477
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₁H₁₄ClN
- Commons category
- Lorcaserin
- isomeric SMILES
- C[C@H]1CNCCC2=C1C=C(C=C2)Cl
- canonical SMILES
- CC1CNCCC2=C1C=C(C=C2)Cl
- World Health Organisation international non-proprietary name
- lorcaserin
via Wikidata · CC0
~8 min read
Encyclopedic overview
18 sectionsContents
- Medical uses
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Approval history
- Society and culture
- Legal status
- Canada
- United States
- Research
- Epilepsy
- See also
- References
- External links
Lorcaserin, marketed under the brand name Belviq, was a weight-loss drug developed by Arena Pharmaceuticals. It reduces appetite by activating the 5-HT2C serotonin receptor in the hypothalamus, a region of the brain which is known to control appetite. It was approved in 2012, and in 2020 was removed from the market in the United States due to an increased risk of cancer detected in users of Belviq.
== Medical uses == Lorcaserin was used long term for weight loss in those who are obese.
Excerpted from Wikipedia’s “lorcaserin” article, available under the CC BY-SA 4.0 licence.