Methyltransferase like 3

Also known as N6-adenosine-methyltransferase 70 kDa subunit, mRNA m(6)A methyltransferase, mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase, methyltransferase-like protein 3, N6-adenosine-methyltransferase catalytic subunit, METTL3, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene. METTL3 is located on the human chromosome 14q11.2 (Cancer Biology) and out of the METTL protein family, it is the most studied.

Article

5 sections

Contents

Function
The m<sup>6</sup>A methyltransferase complex
In cancer
References
Further reading

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m6A). METTL3 forms the m6 a methyltransferase complex with METTL14 and WTP and is responsible for a majority of the m6a modifications of mRNA. The most common modification being the catalyzation of m6a with the methyltransferase complex. METTL3 is expressed in a variety of normal tissues, such as the lymphoid, testis, prostate and fallopian tube tissues. The enzyme is also responsible for mechanisms related to tumor development, RNA stability and maturation, and has suggested roles in ensuring animal survival.