MNDA

Name

myeloid cell nuclear differentiation antigen

Type

protein-coding

Position

158,802,264–158,849,517 (+)

Aliases

PYHIN3

Ensembl

ENSG00000163563

RefSeq RNA

NM_002432.3

RefSeq protein

NP_002423.1

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

myeloid cell nuclear differentiation antigen

Symbol

MNDA

Biotype

Protein coding

Organism

Homo sapiens

Location

1:158,802,264-158,849,517

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MNDA PDB 2dbg.png

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