MOCS2
Sign in to saveAlso known as MCBPE, MOCO1, MOCODB, MPTS, molybdenum cofactor synthesis 2
Molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B are a pair of proteins that in humans are encoded from the same MOCS2 gene. These two proteins dimerize to form molybdopterin synthase.
Gene data
MOCS2- Name
- molybdenum cofactor synthesis 2
- Type
- protein-coding
- Position
- 53,094,141–53,113,016 (−)
- Aliases
- MCBPE, MOCO1, MOCODB, MOCODB1, MPTS
- Ensembl
- ENSG00000164172
- RefSeq RNA
- NM_001444304.1, NM_004531.5, NM_176806.4
- RefSeq protein
- NP_001431233.1, NP_004522.1, NP_789776.1
Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
molybdenum cofactor synthesis 2
- Symbol
- MOCS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:53,094,141-53,113,016
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Gene
- Genetic disease
- Protein structure
- References
- Further reading
Molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B are a pair of proteins that in humans are encoded from the same MOCS2 gene. These two proteins dimerize to form molybdopterin synthase.
== Function == Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin and the catalytically active metal molybdenum. MoCo is synthesized from cyclic pyranopterin monophosphate (precursor Z) by the heterodimeric enzyme molybdopterin synthase.
Excerpted from Wikipedia’s “MOCS2” article, available under the CC BY-SA 4.0 licence.