dihydrofolate reductase
Sign in to saveAlso known as DHFR, uniprot:P00374
mammalian protein found in Homo sapiens
Protein · UniProt
Dihydrofolate reductase
- Gene
- DHFR
- Organism
- Homo sapiens (Human)
- Length
- 187 aa
- Molecular mass
- 21,453 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner (PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595). Key enzyme in folate metabolism. Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway (PubMed:21876188, PubMed:22235121). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2
3D-structureAlternative splicingCytoplasmDisease variantMethotrexate resistanceMitochondrionNADPNucleus
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Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- COMPLETEDDHFR 19 bp Deletion Polymorphism and Folic Acid UtilizationTufts University · NCT03319979
Wikidata facts
- Instance of
- protein
- Image
- PDB 8dfr EBI.jpg
Show 4 more facts
- cell component
- mitochondrion
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P00374
- EC enzyme number
- 1.5.1.4
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