molsidomine

Also known as Cas 276, Corvaton

Molsidomine (trade names Corvasal, Corvaton and many others) is an orally active, short acting vasodilating drug used to treat angina pectoris. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

Key facts

Drug.IUPAC_name: 1-Ethoxy-N-(3-morpholino-5-oxadiazol-3-iumyl)methanimidate
Drug.image: Molsidomine.svg
Drug.image_class: skin-invert-image
Drug.tradename: Corvasal, Corvaton, Molsidain, Molsidolat, others
Drug.routes_of_administration: By mouth (tablets), intravenous infusion
Drug.legal_status: Rx-only
Drug.bioavailability: 44–59%
Drug.protein_bound: 3–11%
Drug.metabolism: Hydrolysis
Drug.metabolites: Linsidomine
Drug.elimination_half life: 1–2 hrs (linsidomine)
Drug.excretion: >90% renal
Drug.CAS_number: 25717-80-0
Drug.ATC_prefix: C01
Drug.ATC_suffix: DX12
Drug.PubChem: 5353788
Drug.DrugBank: DB09282
Drug.ChemSpiderID: 4090

via Wikipedia infobox

Chemical data

Formula: C9H14N4O4
Molecular weight: 242.23 g/mol
IUPAC name: (1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate
SMILES: CCO/C(=N/C1=C[N+](=NO1)N2CCOCC2)/[O-]
InChIKey: XLFWDASMENKTKL-UHFFFAOYSA-N
XLogP: 2.2
Polar surface area: 87 Å²
H-bond donors: 0
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Research

2,197 papers

Molsidomine.Blood vessels · 1990
Molsidomine decreases hyperoxia-induced lung injury in neonatal rats.Pediatric research · 2023
Molsidomine.Lancet (London, England) · 1994
[Molsidomine (Corvaton)].Terapevticheskii arkhiv · 1994
Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats.Animal models and experimental medicine · 2021

via PubMed

Wikidata facts

Mass: 242.101504928
Has use: medication

Show 5 more facts

Commons category: Molsidomine
chemical formula: C₉H₁₄N₄O₄
canonical SMILES: CCOC(=O)\N=C\1/O[N-][N+](=C1)N2CCOCC2
World Health Organisation international non-proprietary name: molsidomine
isomeric SMILES: CCOC(=O)/N=c1/c[n+](N2CCOCC2)[n-]o1

Sources (2)

via Wikidata · CC0

~4 min read

Encyclopedic overview

11 sections

Contents

Medical uses
Contraindications
Side effects
Interactions
Pharmacology
Mechanism of action
Pharmacokinetics
Chemistry
Synthesis
History
References

==Medical uses== Molsidomine is used for the prevention and long-term treatment of stable and unstable angina pectoris, with or without left heart failure. It is also used to treat angina in the context of an acute myocardial infarction.

Excerpted from Wikipedia’s “molsidomine” article, available under the CC BY-SA 4.0 licence.