aminoguanidine
Sign in to saveAminoguanidine is the chemical compound with the formula . It is a versatile synthetic intermediate.
Research
4,115 papers- [Aminoguanidine].Nihon rinsho. Japanese journal of clinical medicine · 1997
- Biological effects of aminoguanidine: an update.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1999
- Aminoguanidine bicarbonate.Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals · 1946
- Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts.Archives of biochemistry and biophysics · 2003
- [Aminoguanidine and impaired wound healing in diabetes].Zhonghua yi xue za zhi · 2004
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Article
5 sectionsContents
- Chemistry
- Synthesis
- Properties
- Investigational drug
- References
Aminoguanidine is the chemical compound with the formula . It is a versatile synthetic intermediate.
Aminoguanidine was studied as an investigational drug for the treatment of diabetic nephropathy, under the nonproprietary name Pimagedine. It is no longer under development as a drug. Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, glyoxal, methylglyoxal, and related dicarbonyls. These reactive species are converted to less reactive heterocycles by this condensation reaction.