Also known as Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
protein-coding gene in the species Homo sapiens
Gene data
MYB- Name
- MYB proto-oncogene, transcription factor
- Type
- protein-coding
- Position
- 135,180,897–135,219,173 (+)
- Aliases
- Cmyb, c-myb, c-myb_CDS, efg
- Ensembl
- ENSG00000118513
- RefSeq RNA
- NM_001130172.2, NM_001130173.2, NM_001161656.2, NM_001161657.2, NM_001161658.2
- RefSeq protein
- NP_001123644.1, NP_001123645.1, NP_001155128.1, NP_001155129.1, NP_001155130.1
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
RNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription activator activity, RNA polymerase II-specificDNA-binding transcription activator activity, RNA polymerase II-specificDNA bindingDNA-binding transcription factor activity
Pathways
via MyGene.info
Gene · Ensembl
MYB proto-oncogene, transcription factor
- Symbol
- MYB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:135,180,897-135,219,173
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Research
11,417 papers- MYB transcription factors in Arabidopsis.Trends in plant science · 2010
- The R2R3-MYB gene family in Arabidopsis thaliana.Current opinion in plant biology · 2001
- Multiple Functions of MYB Transcription Factors in Abiotic Stress Responses.International journal of molecular sciences · 2021
- c-MYB and DMTF1 in Cancer.Cancer investigation · 2019
- Emerging role of MYB transcription factors in cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2024
via PubMed
Wikidata facts
- Instance of
- gene
- Image
- Protein MYB PDB 1guu.png
Show 8 more facts
- HomoloGene ID
- 31311
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4602
- genomic end
- 135540311
- genomic start
- 135181308
- chromosome
- human chromosome 6
- cytogenetic location
- 6q23.3
via Wikidata · CC0