myostatin
Sign in to saveAlso known as growth/differentiation factor 8, MSTN
thumb|In humans, the MSTN gene is located on the long (q) arm of Chromosome 2 (human)|chromosome 2 at position 32.2. Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Wikidata facts
Show 2 more facts
- exact match
- purl.uniprot.org/uniprot/O14793
- Commons category
- Myostatin
Sources (7)
via Wikidata · CC0
~18 min read
Article
23 sectionsContents
- Discovery and sequencing
- Structure and mechanism of action
- Biological advantage
- Effects in animals
- Mutations
- Double-muscled cattle
- Whippets{{anchor|Whippets}}
- Mice
- Rabbits and goats
- Pigs
- Fish
- Clinical significance
- Mutations
- In humans
- Therapeutic potential
- Athletic use
- Lifestyle effects on myostatin
- Effects
- On bone formation
- On the heart
- See also
- References
- External links
thumb|In humans, the MSTN gene is located on the long (q) arm of Chromosome 2 (human)|chromosome 2 at position 32.2. Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Myostatin is assembled and produced in skeletal muscle before it is released into the blood stream. Most of the data regarding the effects of myostatin comes from studies performed on mice.