PARN

Name

poly(A)-specific ribonuclease

Type

protein-coding

Position

14,435,699–14,632,728 (−)

Aliases

DAN, DKCB6, PFBMFT4

Ensembl

ENSG00000274829

RefSeq RNA

NM_001134477.3, NM_001242992.2, NM_002582.4, XM_011522514.3, XM_047434181.1

RefSeq protein

NP_001127949.1, NP_001229921.1, NP_002573.1, XP_011520816.1, XP_047290137.1

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

via MyGene.info

Gene · Ensembl

poly(A)-specific ribonuclease

Symbol

PARN

Biotype

Protein coding

Organism

Homo sapiens

Location

16:14,435,699-14,632,728

Strand

Reverse (−)

Assembly

GRCh38