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GeneQ14912147· pop 5· linked from 98 articles

GDF11

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Also known as BMP-11, BMP11, growth differentiation factor 11, VHO

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. GDF11 is a member of the Transforming growth factor beta family.

Gene data

GDF11
Name
growth differentiation factor 11
Type
protein-coding
Position
55,743,122–55,757,264 (+)
Aliases
BMP-11, BMP11, VHO
Ensembl
ENSG00000135414
RefSeq RNA
NM_001445570.1, NM_005811.5, XM_006719194.4, XM_054370764.1
RefSeq protein
NP_001432499.1, NP_005802.1, XP_006719257.1, XP_054226739.1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016].

Gene Ontology

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)Development of ureteric collection system

via MyGene.info

Gene · Ensembl

growth differentiation factor 11

Symbol
GDF11
Biotype
Protein coding
Organism
Homo sapiens
Location
12:55,743,122-55,757,264
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

7 sections
Contents
  • Tissue distribution
  • Function
  • Effects on cell growth and differentiation
  • Human studies
  • References
  • Further reading
  • External links

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. GDF11 is a member of the Transforming growth factor beta family.

GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and rats. The bone morphogenetic protein group is characterized by a polybasic proteolytic processing site, which is cleaved to produce a protein containing seven conserved cysteine residues.

Excerpted from Wikipedia’s “GDF11” article, available under the CC BY-SA 4.0 licence.

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