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GeneQ18027932· pop 6· linked from 77 articles

INHBC

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Also known as IHBC, inhibin beta C, inhibin beta C subunit, inhibin subunit beta C

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.

Gene data

INHBC
Name
inhibin subunit beta C
Type
protein-coding
Position
57,434,700–57,452,067 (+)
Aliases
IHBC
Ensembl
ENSG00000175189
RefSeq RNA
NM_005538.4
RefSeq protein
NP_005529.1

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016].

Gene Ontology

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)TGF-beta signaling pathway - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Glycoprotein hormonesPeptide hormone biosynthesisPeptide hormone metabolismMetabolism of proteins

via MyGene.info

Gene · Ensembl

inhibin subunit beta C

Symbol
INHBC
Biotype
Protein coding
Organism
Homo sapiens
Location
12:57,434,700-57,452,067
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
21142
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/3626
genomic end
57452062
genomic start
57434784
chromosome
human chromosome 12
cytogenetic location
12q13.3
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.

Excerpted from Wikipedia’s “INHBC” article, available under the CC BY-SA 4.0 licence.

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