نالمفن

Key facts

Drug.Verifiedfields

verified

Drug.Watchedfields

verified

Drug.verifiedrevid

462258343

Drug.image

Nalmefene.svg

Drug.image_class

skin-invert-image

Drug.width

150

Drug.tradename

Revex, others

Drug.MedlinePlus

a605043

Drug.DailyMedID

Nalmefene

Drug.routes_of_administration

By mouth, intranasal, intramuscular, intravenous, subcutaneous

Drug.class

Opioid antagonist

Drug.ATC_prefix

N07

Drug.ATC_suffix

BB05

Drug.legal_AU

S4

Drug.legal_UK

POM

Drug.legal_US

Rx-only

Drug.legal_EU

Rx-only

Drug.bioavailability

40–50% (orally)

via Wikipedia infobox

Chemical data

Formula

C21H25NO3

Molecular weight

339.4 g/mol

IUPAC name

(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol

SMILES

C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O

InChIKey

WJBLNOPPDWQMCH-MBPVOVBZSA-N

XLogP

2.7

Polar surface area

52.9 Ų

H-bond donors

2

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1995

Admin. routes

parenteral, topical

Indications

gambling behaviour, smoking cessation, opioid dependence, atopic eczema

via ChEMBL · EBI

• Nalmefene.2006
• Nalmefene.2012
• Nalmefene Hydrochloride: Potential Implications for Treating Alcohol and Opioid Use Disorder.Substance abuse and rehabilitation · 2024
• Nalmefene combined noninvasive positive-pressure ventilation in Chinese patients with chronic obstructive pulmonary disease coupled with type II respiratory failure: A meta-analysis.Medicine · 2023
• Safety of nalmefene for the treatment of alcohol use disorder: an update.Expert opinion on drug safety · 2020

via PubMed

Wikidata facts

Mass

339.183444

Has use

medication

via Wikidata · CC0