Structure via PubChem · Public domain (PubChem)
nebracetam
Sign in to saveNebracetam is an investigational drug of the racetam family that is a M1 acetylcholine receptor agonist in rats. Based on a human leukemic T cell experiment in 1991, it is believed to act as an agonist for human M1-muscarinic receptors. It is also believed to act as a nootropic, like many other racetam drugs. A chemoenzymatic method of synthesis was reported in 2008. , human trials have not yet been conducted.
Chemical data
- Formula
- C12H16N2O
- Molecular weight
- 204.27 g/mol
- IUPAC name
- 4-(aminomethyl)-1-benzylpyrrolidin-2-one
- SMILES
- C1C(CN(C1=O)CC2=CC=CC=C2)CN
- InChIKey
- LCAFGJGYCUMTGS-UHFFFAOYSA-N
- XLogP
- 0.2
- Polar surface area
- 46.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
28 papers- Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist.Japanese journal of pharmacology · 1991
- Nebracetam (WEB 1881FU) prevents N-methyl-D-aspartate receptor-mediated neurotoxicity in rat striatal slices.Japanese journal of pharmacology · 1992
- Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats.British journal of pharmacology · 1997
- Effect of nebracetam on content of high-energy phosphates and morphometry of rat astrocytes in vitro. Comparison with piracetam.Acta poloniae pharmaceutica · 2000
- Increase of acetylcholine release by nebracetam in dog cardiac sympathetic ganglion.The Journal of pharmacology and experimental therapeutics · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 204.126
Show 3 more facts
- chemical formula
- C₁₂H₁₆N₂O
- canonical SMILES
- C1C(CN(C1=O)CC2=CC=CC=C2)CN
- subject has role
- parasympathomimetic drug
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Nebracetam is an investigational drug of the racetam family that is a M1 acetylcholine receptor agonist in rats. Based on a human leukemic T cell experiment in 1991, it is believed to act as an agonist for human M1-muscarinic receptors. It is also believed to act as a nootropic, like many other racetam drugs. A chemoenzymatic method of synthesis was reported in 2008. , human trials have not yet been conducted.
== See also == Piracetam Aniracetam Racetam
Excerpted from Wikipedia’s “nebracetam” article, available under the CC BY-SA 4.0 licence.