Structure via PubChem · Public domain (PubChem)
nefiracetam
Sign in to saveNefiracetam is a nootropic drug of the racetam family. Preliminary research suggests that it may possess certain antidementia properties in rats.
Chemical data
- Formula
- C14H18N2O2
- Molecular weight
- 246.3 g/mol
- IUPAC name
- N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
- SMILES
- CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O
- InChIKey
- NGHTXZCKLWZPGK-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 49.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Alzheimer disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 246.137
Show 2 more facts
- chemical formula
- C₁₄H₁₈N₂O₂
- canonical SMILES
- CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Effects
- Pharmacology
- Concerns
- See also
- References
Nefiracetam is a nootropic drug of the racetam family. Preliminary research suggests that it may possess certain antidementia properties in rats.
==Effects== Nefiracetam's cytoprotective actions are mediated by enhancement of GABAergic, cholinergic, and monoaminergic neuronal systems. Preliminary studies suggest that it improves apathy and motivation in post-stroke patients. It may also exhibit antiamnesia effects for the Alzheimer's type and cerebrovascular type of dementia. In addition, research in animal models suggests antiamnesic effects against a number of memory impairing substances, including: ethanol, chlorodiazepoxide, scopolamine, bicuculline, picrotoxin, and cycloheximide.
Excerpted from Wikipedia’s “nefiracetam” article, available under the CC BY-SA 4.0 licence.