nerve growth factor
Sign in to saveAlso known as nerve growth factor (beta polypeptide), beta-nerve growth factor, NGF, pro-nerve growth factor long, nerve growth factor, beta subunit
mammalian protein found in Homo sapiens
Protein · UniProt
Beta-nerve growth factor
- Gene
- NGF
- Organism
- Homo sapiens (Human)
- Length
- 241 aa
- Molecular mass
- 26,959 Da
- Evidence
- 1: Evidence at protein level
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable) (PubMed:20978020). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neurona…
Swiss-Prot (reviewed) · via UniProt
Research
88,293 papers- Nerve growth factor in the psychiatric brain.Rivista di psichiatria · 2020
- Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases.International journal of molecular sciences · 2021
- Nerve growth factor in metabolic complications and Alzheimer's disease: Physiology and therapeutic potential.Biochimica et biophysica acta. Molecular basis of disease · 2020
- Anti-nerve growth factor antibodies for the treatment of low back pain.Expert review of clinical pharmacology · 2020
- Neurotrophic factors and nerve growth factor in ocular allergy.Current opinion in allergy and clinical immunology · 2019
via PubMed
Clinical Trials
355 registered- PHASE4COMPLETEDStudy of 2 Doses of Solifenacin Succinate in Female Subjects With Overactive Bladder.Astellas Pharma Inc · NCT01093534
- NACOMPLETEDThe Effect of Endurance Training on Motor and Cognitive Functions and Concentration of Biomarkers in Post-stroke PatientsPoznan University of Physical Education · NCT06824116
- PHASE1WITHDRAWNPhase I Trial of Vandetanib Combined With 131I-mIBG to Treat Patients With Advanced Phaeochromocytoma and ParagangliomaUniversity College, London · NCT01941849
- RECRUITINGNeurotrophic Factors, Impulsivity, and Reward Sensitivity in Children With Internet Gaming DisorderIstanbul Saglik Bilimleri University · NCT07590180
- PHASE2COMPLETEDAutologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS)Brainstorm-Cell Therapeutics · NCT01777646
- PHASE2COMPLETEDEffect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured PatientsBuddhist Tzu Chi General Hospital · NCT01682603